Award
National Heart, Lung, and Blood Institute 7R01HL160808-04
HUMAN PLATELET PAR4: NOVEL ACTIVATION, INTERINDIVIDUAL VARIATION, AND NEUTROPHIL INTERACTIONS IN VIVO AND IN VITRO
Recipient
Washington University, Saint Louis, MO, United States
Award Amount
$509,165.00
Ceiling
$509,165.00
Awarded
January 07, 2025
Identifier
7R01HL160808-04
This award funds research on genetic and molecular mechanisms of platelet function and stroke risk, focusing on PAR4 receptor variants to develop targeted therapies for ischemic vascular disease.
Description
The research aims to understand the molecular genetic mechanisms contributing to blood platelet reactivity and stroke outcomes, with the goal of developing targeted therapies for ischemic vascular disease. The study involves genetic analysis of PAR4 receptor variants, their role in platelet activation, and their impact on stroke and hemorrhage in murine models.