Award
NIH Reporter #5R01CA098571-21
Molecular Mechanisms of eIF4E Mediated Transformation
Recipient
Northwestern University, Chicago, IL
Award Amount
$397,035.00
Ceiling
$397,035.00
Awarded
July 17, 2025
Identifier
5R01CA098571-21
Research project funded by the National Cancer Institute to study the role of eIF4E in cancer, particularly its impact on RNA splicing and potential therapeutic interventions for high-eIF4E cancers and AML.
Description
This project investigates the role of the protein eIF4E in cancer development, focusing on its mechanisms in RNA processing and splicing. The research aims to develop new therapeutic strategies for high-eIF4E cancers by exploring eIF4E-dependent alterations in splicing, its interactions with the spliceosome, and its impact on acute myeloid leukemia (AML).