Award
National Institute of Allergy and Infectious Diseases 5R21AI178424-02
A non-canonical role of Caspase-1 in regulating bacterial antimicrobial resistance
Recipient
Institute for Systems Biology, Seattle, WA, United States
Award Amount
$235,000.00
Ceiling
$235,000.00
Awarded
August 06, 2025
Identifier
5R21AI178424-02
The award supports research on the role of Caspase-1 in reducing antimicrobial resistance in intracellular Salmonella by inhibiting the PhoPQ system, potentially revealing new mechanisms of host-pathogen interaction.
Description
This project investigates the non-canonical role of Caspase-1 in controlling bacterial signaling and antimicrobial resistance, specifically how Caspase-1 inhibits PhoPQ activation and CAMP resistance of intracellular Salmonella independent of its protease activity.