Award
NIH Reporter #5R00GM146028-05
Structural consequences of PKC-dependent phosphorylation of Kv7.2
Recipient
University of Arkansas at Fayetteville, Fayetteville, AR, United States
Award Amount
$249,000.00
Ceiling
$249,000.00
Awarded
August 14, 2026
Identifier
5R00GM146028-05
This NIH grant supports research investigating the molecular mechanisms of M-channel regulation via phosphorylation effects on Kv7.2, contributing to understanding epilepsy.
Description
M channels are critical for regulating neuronal excitability. Dysfunction can cause epilepsy. The study aims to elucidate how phosphorylation at S520 and S527 affects PIP2 and CaM binding to Kv7.2, influencing M channel activity, using advanced NMR techniques.