Award
National Institute of Neurological Disorders and Stroke 5R01NS129860-04
Mechanisms of Pol II Elongation in Diffuse Midline Glioma
Recipient
Baylor College of Medicine, Houston, TX
Award Amount
$466,165.00
Ceiling
$466,165.00
Awarded
January 22, 2026
Identifier
5R01NS129860-04
Research project funded by NINDS to study how Pol II elongation regulators contribute to tumorigenesis in diffuse midline glioma with histone H3 mutations, aiming to identify therapeutic targets.
Description
This project aims to characterize the roles of genes regulating RNA Polymerase II (Pol II) transcriptional elongation in promoting diffuse midline glioma (DMG) tumorigenesis, focusing on the oncogenic histone H3 mutations (H3.3K27M and H3.1K27M). The research investigates how mutant histones co-opt elongation factors to induce aberrant transcription, contributing to tumor development.