Award
NIH Reporter #5R01AI165697-05
Specification of Treg cells: learning from FoxP3 deficiencies
Recipient
Harvard Medical School, Boston, MA, United States
Award Amount
$556,016.00
Ceiling
$556,016.00
Awarded
June 08, 2026
Identifier
5R01AI165697-05
Research project studying the role of FoxP3 in T regulatory cells to understand immune regulation and autoimmune disease mechanisms using advanced molecular biology techniques and animal models.
Description
The project focuses on the role of the transcription factor FoxP3 in T regulatory cells, exploring molecular and functional defects caused by mutations, with implications for understanding IPEX disease. The research involves single-cell RNA sequencing, chromatin mapping, CRISPR editing in mice, and microscopy to study mutation-specific effects on gene expression, chromatin architecture, and autoimmune phenotypes.