Award
National Institute of General Medical Sciences 5R35GM141835-05
Cell cycle checkpoint control in C. elegans
Recipient
University of California Santa Cruz
Award Amount
$385,000.00
Ceiling
$385,000.00
Awarded
May 14, 2025
Identifier
5R35GM141835-05
The project investigates cell cycle checkpoint control in C. elegans to understand how chromosome segregation is regulated across different cell types, which is critical for preventing chromosomal abnormalities linked to cancer, infertility, miscarriages, and birth defects.
Description
This NIH-funded project aims to elucidate the mechanisms of cell cycle checkpoint regulation across different cell types in C. elegans, with implications for understanding chromosomal stability in multicellular organisms. The research analyzes the function and regulation of essential checkpoint factors in cells that vary in size, shape, fate, and tissue in C. elegans to identify mechanisms that guarantee proper chromosome segregation in all cell types.