Award
National Institute of Arthritis and Musculoskeletal and Skin Diseases 5R01AR075121-05
Intra-cartilage depot delivery of electrically-charged IL-1RA for targeting osteoarthritis-associated inflammation and catabolism in multiple joint tissues
Recipient
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Award Amount
$383,356.00
Ceiling
$383,356.00
Awarded
July 21, 2025
Identifier
5R01AR075121-05
Award for research on electrically charged IL-1RA delivery targeting osteoarthritis inflammation and catabolism in joint tissues.
Description
This project focuses on developing electrically charged IL-1RA for targeted delivery in osteoarthritis treatment, with a focus on cartilage penetration and retention. The project involves developing conjugates with Avidin and CPC, characterizing transport properties, evaluating biological efficacy, and assessing therapeutic potential in animal models.