Award
National Institute on Drug Abuse 5R01DA060755-03
HIV Tat and Opiate-mediated aberrations in glial-neuronal crosstalk: Implications for the role of extracellular RNA in HAND
Recipient
University of Nebraska Medical Center, Omaha, NE
Award Amount
$517,330.00
Ceiling
$517,330.00
Awarded
April 21, 2026
Identifier
5R01DA060755-03
This NIH-funded project studies the combined effects of HIV Tat protein and opiates on brain cell communication, particularly through extracellular RNA, to address neurocognitive impairments in HIV patients and develop RNA-based treatments.
Description
The project investigates how HIV Tat and opiates affect glial-neuronal interactions, focusing on extracellular RNA's role in HIV-associated neurocognitive disorders (HAND). It aims to understand molecular pathways and develop RNA therapeutics for HIV and opioid co-morbidities.