Award
NIH Reporter #5F32HL178155-02
Investigating the Role of Extracellular Matrix in Down Syndrome Associated Cardiac Phenotypes.
Recipient
Massachusetts Institute of Technology
Award Amount
$82,348.00
Ceiling
$82,348.00
Awarded
February 27, 2026
Identifier
5F32HL178155-02
Research project funded by the National Heart Lung and Blood Institute to study extracellular matrix roles in cardiac defects associated with Down Syndrome, using advanced 3D cardiac models to understand mechanisms and develop potential therapies.
Description
This project investigates how extracellular matrix disruption during heart development affects cell signaling and nuclear architecture, contributing to congenital heart defects in Down Syndrome. It uses 3D cardiac models to study ECM-integrin circuits and nuclear organization, aiming to develop therapies to minimize DS phenotypes and other ECM-related diseases.