Award
National Heart, Lung, and Blood Institute 5R01HL060190-20
Metabolic reprogramming of smooth muscle cells in pulmonary hypertension
Recipient
Florida International University
Award Amount
$628,894.00
Ceiling
$628,894.00
Awarded
April 27, 2026
Identifier
5R01HL060190-20
This award funds research on the metabolic reprogramming of smooth muscle cells in pulmonary hypertension, focusing on mitochondrial bioenergetics and signaling pathways as potential therapeutic targets.
Description
Pulmonary hypertension (PH) is a devastating disease involving excessive proliferation and impaired apoptosis of pulmonary vessel cells, leading to vascular obstruction, right ventricular hypertrophy, and death. The project investigates mitochondrial bioenergetics and signaling pathways, particularly involving mitochondrial PKG-Iα, as therapeutic targets.