Award
National Institute of General Medical Sciences 5R35GM149320-04
Coordination of DNA Metabolism by Replication Protein A
Recipient
Saint Louis University
Award Amount
$546,612.00
Ceiling
$546,612.00
Awarded
April 29, 2026
Identifier
5R35GM149320-04
Award to Saint Louis University by the National Institute of General Medical Sciences for research on the coordination of DNA metabolism by Replication Protein A, focusing on its interactions and regulatory mechanisms to maintain genomic integrity and develop new chemotherapeutics.
Description
This project investigates the molecular mechanisms of Replication Protein A (RPA) in DNA metabolism, including replication, repair, recombination, and telomere maintenance. The research focuses on RPA interactions, regulation, and function, particularly how RPA's flexible architecture enables its roles in DNA metabolic processes. The study involves structural, biochemical, and biophysical investigations and aims to develop novel chemotherapeutics targeting DNA repair pathways.