Award
NIH Reporter #1R21AI193594-01A1
Analysis of the AgrA-mediated transcription regulation in Listeria monocytogenes
Recipient
Tufts University
Award Amount
$247,500.00
Ceiling
$247,500.00
Awarded
May 19, 2026
Identifier
1R21AI193594-01A1
The award supports research on the transcriptional regulation of virulence genes in Listeria monocytogenes by the AgrA regulator, aiming to understand its role in bacterial virulence and biofilm development through genome-wide binding site analysis.
Description
This project aims to elucidate the complex regulation of virulence genes in Listeria monocytogenes, with potential implications for food safety and infectious disease control. The research focuses on the regulation of virulence genes involving AgrA, CodY, and MouR regulators, using genome-wide analysis including ChIP-seq and DNA affinity purification. The project will characterize the mechanisms of triple regulation of the agr locus and identify the direct targets of AgrA to understand its role in modulating listerial virulence.