Award
NIH Reporter #5R21AI193780-02
Using a Superoxide Dismutase Mimetic to Mitigate Age-Associated, Radiation-Induced Cardiopulmonary Damage: Investigating the Role of Nitro-Oxidative Signaling and Mitochondrial Metabolism
Recipient
University of Iowa, Iowa City, IA, United States
Award Amount
$155,500.00
Ceiling
$155,500.00
Awarded
August 13, 2026
Identifier
5R21AI193780-02
The award funds research to study how nitro-oxidative metabolism affects mitochondrial function and cardiopulmonary health in aging, focusing on mitigating radiation-induced damage using a superoxide dismutase mimetic.
Description
This project investigates the impact of nitro-oxidative metabolism on mitochondrial electron transport chain efficiency and cardiopulmonary physiology using genetically modified mice and an upper body irradiation model. It aims to assess the efficacy of a superoxide dismutase mimetic (Rucosopasem) in reducing ionizing radiation-induced cardiopulmonary effects, potentially unveiling targets to prevent or mitigate these toxicities in an aging population.