Award
National Institute of Allergy and Infectious Diseases 5R01AI178848-03
Development and application of a quantitive model for HIV-1 transcriptional activation driven by TAR RNA conformational dynamics
Recipient
Columbia University Health Sciences
Award Amount
$796,527.00
Ceiling
$796,527.00
Awarded
August 18, 2025
Identifier
5R01AI178848-03
The project develops technologies to quantitatively model HIV-1 TAR RNA transcriptional activation by integrating experimental data and computational simulations to predict cellular function and inform therapeutic interventions.
Description
This project aims to develop a quantitative, predictive understanding of HIV-1 TAR RNA's role in viral transcription, leveraging advanced experimental and computational techniques to inform therapeutic strategies.