Award
National Institute of Allergy and Infectious Diseases 5R01AI185510-02
Influence of hypoxia on the antiviral functions of human intestinal epithelial cells
Recipient
University of Florida, Gainesville, FL, United States
Award Amount
$646,188.00
Ceiling
$646,188.00
Awarded
April 03, 2026
Identifier
5R01AI185510-02
Research project funded by NIAID to study the impact of hypoxia on antiviral immune functions in intestinal epithelial cells, aiming to develop new treatments for enteric viruses and inflammatory bowel diseases.
Description
This project investigates how hypoxia affects innate immune responses in human intestinal epithelial cells using human enteric viruses, intestinal organoids, and gut-on-a-chip technologies. The research aims to understand hypoxia-mediated immune inhibition and develop therapeutics targeting hypoxia responses to treat enteric viruses and related diseases.