Award
National Institute of General Medical Sciences 5R01GM149666-04
The roles of p53 and MYC dynamics in regulating heterogeneous cell fate responses to genotoxic stress
Recipient
University of Minnesota, Minneapolis, MN, United States
Award Amount
$324,260.00
Ceiling
$324,260.00
Awarded
January 16, 2026
Identifier
5R01GM149666-04
Research project funded by the National Institute of General Medical Sciences to study how p53 and MYC transcription factors regulate cell fate responses to DNA damage, with implications for cancer therapy.
Description
This project aims to elucidate the mechanisms by which p53 and MYC regulate cell fate decisions under genotoxic stress, with potential implications for cancer therapy and understanding tumor heterogeneity. The research involves time-lapse fluorescence microscopy and analysis of gene expression at the single-cell level to determine how p53 and MYC dynamics control apoptosis and senescence in response to DNA damage.