# NIH Reporter #1R43HL178322-01A1

A cardiopulmonary unit-on-a-chip to investigate the pathophysiology and develop targeted treatments for right ventricular hypertrophy caused by pulmonary arterial hypertension

**Recipient:** Adnan Akif

**Award Amount:** $227,639.00
**Ceiling:** $227,639.00

**Awarded:** August 31, 2026

**Identifier:** 1R43HL178322-01A1

This NIH-funded project aims to create an innovative 'organ-on-a-chip' model to better understand and develop treatments for PAH-related RVH, with a focus on sex differences and personalized medicine.

### Description

This project involves developing a microfluidic 'cardiopulmonary-unit-on-a-chip' to model right ventricular hypertrophy (RVH) caused by pulmonary arterial hypertension (PAH). The model aims to incorporate features such as rhythmic contraction, blood flow-induced pressure, and electrical stimulation, and will be used to study sex differences and test medications.

[View original record](https://reporter.nih.gov/search/IgE1H2ioLUOz0qmA4MDg0Q/project-details/11410451)