Award
National Institute of General Medical Sciences 5R01GM144547-04
Epigenetic mechanisms of regulation of histone lysine methyltransferases involved in leukemia
Recipient
New York University School of Medicine
Award Amount
$452,033.00
Ceiling
$452,033.00
Awarded
July 08, 2026
Identifier
5R01GM144547-04
Research project funded by the National Institute of General Medical Sciences to study histone lysine methyltransferases involved in leukemia, aiming to understand their regulation and develop new therapies.
Description
This project focuses on the roles of Dot1 and COMPASS/MLL1 histone lysine methyltransferases in gene regulation and their deregulation in leukemias. The research aims to elucidate the mechanisms underlying their regulation using biochemical, biophysical, and structural methods, with validation in cells and in vivo. The goal is to discover novel therapeutic strategies for diseases associated with their deregulation.