Award
National Eye Institute 5R01EY036070-02
Cholinergic Dysfunction in Glaucoma
Recipient
Stanford University
Award Amount
$695,050.00
Ceiling
$695,050.00
Awarded
June 12, 2026
Identifier
5R01EY036070-02
NIH-funded research project investigating cholinergic nervous system dysfunction in glaucoma using advanced imaging and neurochemical analysis to identify therapeutic targets.
Description
The study aims to investigate the role of the cholinergic nervous system in glaucoma, focusing on structural, metabolic, and functional changes in visual pathways. It involves developing non-invasive imaging techniques such as MRI and MRS to assess cholinergic dysfunction in both patients and animal models. The research includes testing cholinergic lesioning, neuromodulation, and supplementation in rat models, as well as examining neurochemical changes in human glaucoma patients.