Award
NIH Reporter #4R00GM152790-03
Regulation of exon junction complex composition and assembly
Recipient
University of Kentucky, Lexington, KY, United States
Award Amount
$249,000.00
Ceiling
$249,000.00
Awarded
August 10, 2026
Identifier
4R00GM152790-03
This award supports research on the regulation of exon junction complexes, their composition, and assembly, particularly how insulin signaling influences these processes. The goal is to understand mechanisms of gene expression regulation and their implications in human diseases.
Description
The project focuses on understanding the regulation of exon junction complexes (EJCs) and their role in gene expression and human disease. The research involves defining how insulin signaling affects EJC composition and how cells form different types of EJCs. The study aims to provide insights into mechanisms that could be targeted for therapeutic interventions in diseases related to EJC dysregulation.