NIH Reporter #3R01AI175941-04S2

Defining correlates of protection from dengue illness in a long-term cohort study of multigenerational house-holds in Thailand

The award funds a research study to identify immune correlates of protection against dengue illness by studying a long-term multigenerational cohort in Thailand, focusing on early immune exposures and their impact on dengue immunity and illness risk.

Description

This study will leverage an established and uniquely long-term family cohort study for DENV in Thailand to define how the early immune environment to DENV, as shaped by maternally-transferred DENV antibodies and the timing and features of early DENV and non-DENV flavivirus exposures, shapes an individual’s future antibody-mediated immune profiles to DENV and subsequent risks of dengue illness. This proposed research is relevant for human health because it will identify features of exposure histories and pre-infection immunity associated with protection from dengue illness, ultimately supporting the identification of correlates of protection, which are critically needed for public health surveillance and countermeasure development.

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