Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK132017-05
Endoplasmic Reticulum stress and thyroid cell death
Recipient
University of Michigan at Ann Arbor
Award Amount
$390,000.00
Ceiling
$390,000.00
Awarded
March 30, 2026
Identifier
5R01DK132017-05
Research grant investigating mechanisms of thyroid cell death related to ER stress and thyroglobulin secretion defects, with implications for hypothyroidism and thyroid disorders.
Description
This grant concentrates on defective thyroglobulin secretion linked to thyroid cell death, which is connected to a range of very common clinical thyroid disorders. The project aims to investigate the mechanisms of ER stress-dependent and independent thyrocyte death, using animal models such as knock-in mice and heterozygous mutants. It explores the role of ER-associated protein degradation (ERAD), thyroid cell extrusion, and iodination processes in thyroid pathology.