Award
Food and Drug Administration 5U18FD008342-02
Validation of Endopep-MS for qualitative detection of BoNT/A, /C, /CD, /D, and /DC in animal specimens and feed.
Recipient
University of California at Davis
Award Amount
$49,689.00
Ceiling
$49,689.00
Awarded
August 25, 2025
Identifier
5U18FD008342-02
The award funds the validation of the Endopep-MS method for detecting botulinum toxins in animal specimens and feed, aiming to improve rapid testing and reduce reliance on mouse bioassays.
Description
This project aims to validate the Endopep-MS method, develop monoclonal antibodies for toxin extraction, and assess polyclonal antibodies' effectiveness, to support rapid botulism testing and reduce reliance on mouse bioassays. Botulism is a serious paralytic disease affecting humans and animals caused by botulinum toxins. The project will enable rapid detection of multiple botulinum toxin serotypes in feed and animal samples, leading to early diagnosis of botulism.