Award
National Institute of General Medical Sciences 5R01GM102187-13
Chemical Tools for Probing Cysteine Sulfenation and Sulfination Redox Biology
Recipient
Kate Suzanne Carroll
Award Amount
$312,625.00
Ceiling
$312,625.00
Awarded
December 10, 2025
Identifier
5R01GM102187-13
This NIH/NIGMS funded project focuses on developing chemical tools to study cysteine modifications in proteins, aiming to understand their regulatory roles and implications in disease mechanisms. The award amount is $312,625 for FY 2026, with a project duration from 2012 to 2026.
Description
The project involves development and application of chemical methods to address spatiotemporal control in redox signaling, genetic incorporation of oxidized cysteine in proteins, and discovery of covalent ligands targeting redox-regulated proteins. The project aims to elucidate regulatory functions of protein cysteine residues and provide frameworks for understanding disease mechanisms related to cysteine modifications.