Award
National Cancer Institute 5R00CA277554-04
Dissecting the Myeloid-Th17 axis in the pathogenesis of Colitis-associated Colorectal Cancer
Recipient
University of Alabama at Birmingham
Award Amount
$248,932.00
Ceiling
$248,932.00
Awarded
January 28, 2026
Identifier
5R00CA277554-04
Research project funded by the National Cancer Institute to study the role of myeloid cells and Th17 cells in colorectal cancer inflammation, focusing on IL-39 cytokine's role and potential therapeutic strategies.
Description
This project explores the critical role of myeloid cells and T helper 17 cells (Th17) in maintaining an inflammatory tumor microenvironment in the colon and addresses a novel role of neutrophil-derived Interleukin-39 in promoting Th17 development. Understanding the cellular and molecular mechanisms underpinning tumor-promoting inflammation will help design new therapeutic strategies for colorectal cancer and inflammatory bowel disease.