Award
NIH Reporter #2R01HG010501-05A1
Impact of Coding Variation on Transcription Factor - DNA Recognition
Recipient
BRIGHAM AND WOMEN'S HOSPITAL
Award Amount
$3,514,198.00
Ceiling
$3,514,198.00
Awarded
August 28, 2026
Identifier
2R01HG010501-05A1
This NIH-funded project aims to understand how genetic variations in transcription factors affect DNA binding and gene regulation by developing new analytical methods and predictive models.
Description
The project focuses on developing new methods for analyzing transcription factor (TF)-DNA binding, identifying effects of TF mutations on DNA binding activity and gene regulation, learning amino acid sequence determinants of TF DNA binding specificity, and developing predictive models of the effects of TF coding variants on DNA binding activity. The goal is to increase understanding of how genetic variation in TFs impacts DNA binding and gene regulation, potentially disrupting cellular phenotypes.