National Institute of General Medical Sciences 1R35GM166114-01

Structural basis of lyssavirus glycoprotein fusion, receptor binding, and organization

NIH-funded project at Montana State University to study lyssavirus glycoprotein structure and function using cryo-EM, aiming to advance understanding of viral infection and support antiviral and gene therapy development.

Description

This project uses lyssavirus glycoproteins as a model system to study viral fusion, receptor binding interactions, and glycoprotein assembly. The research aims to capture rabies virus glycoprotein fusion intermediates, determine how it binds to the p75 neurotrophin receptor, and analyze glycoprotein structure and contacts influencing organization on the virus. Outcomes will provide a structural atlas of key steps in viral infection, aiding virology research, antiviral development, and gene therapy vectors.

View original record