Award
National Cancer Institute 1R15CA277652-01
The Design and Study of Anticancer Therapeutics Inspired by Natural Substrates of LAT1
Recipient
Georgia Southern University, Statesboro, GA
Award Amount
$424,715.00
Ceiling
$424,715.00
Awarded
February 08, 2023
Identifier
1R15CA277652-01
The award supports research to design and study anticancer therapeutics inspired by natural substrates of LAT1, focusing on developing novel amino acid chemotherapeutics to target cancer cell proliferation.
Description
This project aims to develop novel 1,2,3-triazole-based amino acid chemotherapeutics as structural analogues of natural LAT1 substrates, utilizing innovative design and biological evaluation to enhance anticancer activity and cellular uptake. Research objectives include designing and synthesizing triazole-based amino acid-drug assemblies and conducting in vitro characterization of drug candidates.