Award
NIH Reporter #1R15GM159232-01
Examining Glycine Receptor's Intracellular Domain by Crosslinking-Mass Spectrometry
Recipient
Duquesne University, Pittsburgh, PA, United States
Award Amount
$512,397.00
Ceiling
$512,397.00
Awarded
September 11, 2025
Identifier
1R15GM159232-01
A research project funded by the National Institute of General Medical Sciences to study glycine receptor intracellular domains using crosslinking mass spectrometry, aiming to understand receptor structure and interactions relevant to neuronal communication.
Description
This project aims to study the structure of the intracellular domain (ICD) of glycine receptors (GlyRs) in lipid bilayers using crosslinking mass spectrometry (CXMS). The research will focus on the allosteric states of GlyRs and their interactions with lipids, providing insights into a previously unresolved domain.