Award
National Institute of Dental and Craniofacial Research 5R01DE032018-05
Harnessing the nervous system to overcome resistance to immunotherapy in oral cancer
Recipient
University of TX MD ANDERSON CAN CTR
Award Amount
$678,424.00
Ceiling
$678,424.00
Awarded
June 16, 2026
Identifier
5R01DE032018-05
Research project funded by the National Institute of Dental and Craniofacial Research to study neuronal mechanisms in oral cancer and develop therapies to overcome immunotherapy resistance.
Description
This project aims to elucidate the neuronal mechanisms supporting tumor progression and immune evasion in oral cancer. It focuses on neuro-immune crosstalk, tumor-associated neurons (TANs), and their role in creating an immunosuppressive microenvironment. The research involves advanced spatial imaging and genomic approaches to identify targets for therapy and overcome immunotherapy resistance.