Award
NIH Reporter #1R01AI193490-01A1
Using the Collaborative Cross to elucidate genetic and immune factors mediating chikungunya virus neuropathogenesis
Recipient
Texas Biomedical Research Institute, San Antonio, TX, United States
Award Amount
$962,661.00
Ceiling
$962,661.00
Awarded
August 28, 2026
Identifier
1R01AI193490-01A1
The award supports research using genetically diverse mouse models to study chikungunya virus-induced neurological disease, aiming to understand genetic and immune factors influencing disease susceptibility and progression.
Description
This project aims to develop and utilize genetically diverse mouse models to study the mechanisms of chikungunya virus-induced neurological disease, with the goal of informing countermeasure development against this pandemic threat. The proposal will use mouse strains from the Collaborative Cross to develop and characterize improved mouse models of neurological chikungunya virus infection and identify genetic and immune factors that contribute to susceptibility and disease pathology.