Award
NIH Reporter #3P01AG073084-05S1
Aging as a Risk Factor and Target for Prevention of Liver Cancer
Recipient
Sanford Burnham Prebys Medical Discovery Institute
Awarded
August 31, 2026
Identifier
3P01AG073084-05S1
Research project focused on understanding how aging influences liver cancer risk and developing early detection and prevention strategies through various biological studies and interventions.
Description
This project aims to investigate the mechanisms underlying age-dependence of liver cancer and test candidate early detection and preventative approaches. It involves multiple objectives including studying age-related changes in mitochondria, chromatin, metabolism, and immune function, and testing interventions such as senolytics, rapamycin, and bile acid modulators to prevent and treat liver cancer.