Award
National Institute of General Medical Sciences 5R35GM134962-07
Structure and Mechanism of G-proteins and cell adhesion proteins in regulation of cell growth and motility
Recipient
University of North Carolina at Chapel Hill, Department of Biochemistry
Award Amount
$602,153.00
Ceiling
$602,153.00
Awarded
January 14, 2026
Identifier
5R35GM134962-07
This award funds research on the mechanisms of G-protein activation and cell adhesion proteins, aiming to understand their roles in cell growth and motility, with potential therapeutic implications for diseases such as cancer and cardiovascular disorders.
Description
The project investigates mechanisms governing G-protein activation and signaling, focusing on the RAS superfamily and heterotrimeric Gα-proteins, and their regulation through allosteric networks and pH modulation. It also explores cell adhesion proteins, vinculin and metavinculin, their roles in cell morphology, force transmission, and motility, and how metavinculin mutations affect adhesion and contractile force. Employing multidisciplinary approaches, the research aims to advance understanding of G-protein regulation and cell adhesion, with implications for targeted therapies in related diseases.