Award
Eunice Kennedy Shriver National Institute of Child Health and Human Development 5R01HD110467-04
Perinatal Gonadal Hormones Impart Male-Biased Neuroimmune, Mitochondrial, and Behavioral Vulnerabilities
Recipient
Massachusetts General Hospital, Boston, MA, United States
Award Amount
$523,148.00
Ceiling
$523,148.00
Awarded
May 19, 2026
Identifier
5R01HD110467-04
NIH awarded a research grant to Massachusetts General Hospital to study how perinatal gonadal hormones affect male-biased neuroimmune and mitochondrial vulnerabilities, potentially explaining sex differences in neurodevelopmental disorders.
Description
This R01 proposal tests the central hypothesis that hormones present during a critical window of perinatal brain organization result in distinct sex-specific microglial and mitochondrial phenotypes that increase male vulnerability to perinatal immune stimuli. The project investigates the role of microglial estrogen and androgen receptors in male-biased neurodevelopmental disorder vulnerabilities.