Award
National Center for Advancing Translational Sciences 1R21TR006405-01
Development of Small Molecules that Activate PTP1B and OtherPhosphatases
Recipient
STATE UNIVERSITY OF NEW YORK AT ALBANY
Award Amount
$430,375.00
Ceiling
$430,375.00
Awarded
July 20, 2026
Identifier
1R21TR006405-01
This award funds research to develop small molecule activators of protein tyrosine phosphatases (PTPs) to modulate redox signaling pathways for therapeutic purposes, leveraging novel strategies to overcome historical challenges in drug development targeting PTPs.
Description
The project focuses on elucidating redox signaling mechanisms underlying disease initiation and progression and developing therapeutic strategies targeting deregulated pathways, specifically activating protein tyrosine phosphatases (PTPs) using novel approaches including allosteric activation with electron-rich molecules and preventing key protein-protein interactions controlling their redox state in vivo.