Award
National Institute of Allergy and Infectious Diseases 5R01AI167629-04
Cervicovaginal microbiome, mucosal immunity, and pathogen factors that contribute to spontaneous clearance of Chlamydia trachomatis
Recipient
University of Maryland Baltimore, Baltimore, MD
Award Amount
$783,147.00
Ceiling
$783,147.00
Awarded
June 05, 2025
Identifier
5R01AI167629-04
Research project funded by NIAID to study factors influencing spontaneous clearance of Chlamydia trachomatis, focusing on vaginal microbiome, immune response, and pathogen characteristics to aid vaccine and treatment development.
Description
This project aims to assess how the vaginal microbiome, characteristics of the infecting Chlamydia trachomatis organism, and immune responses affect spontaneous clearance of Chlamydia trachomatis without antibiotics. It involves analyzing archived cervicovaginal lavage samples from a longitudinal study of 3,620 women to identify immunologic, metabolomic, and bacterial factors associated with spontaneous clearance, informing future vaccine development and antibiotic-sparing strategies.