Award
National Heart, Lung, and Blood Institute 5R01HL181370-02
Erythroblastic island macrophages in normal erythropoiesis and disordered erythropoiesis in polycythemia vera
Recipient
New York Blood Center
Award Amount
$785,595.00
Ceiling
$785,595.00
Awarded
May 05, 2026
Identifier
5R01HL181370-02
NIH grant awarded to New York Blood Center to study the role of erythroblastic island macrophages in normal and disordered erythropoiesis, focusing on EPO/EPOR signaling and JAK2 mutations in polycythemia vera.
Description
This project investigates how central macrophages support erythropoiesis via EPO/EPOR signaling and how JAK2 mutations contribute to overproduction of red blood cells in polycythemia vera. The study aims to define mechanisms of normal and disordered erythropoiesis, with potential implications for new treatments for anemia and erythrocytosis.