Award
NIH Reporter #11172647
The functional role of DDX41 in myelodysplastic syndromes
Recipient
Not Specified
Awarded
October 01, 2023
Identifier
11172647
This award supports research on the role of the DDX41 gene in myelodysplastic syndromes, aiming to uncover how its deficiency affects blood cell development and leads to cell death, potentially guiding new treatments.
Description
Research project investigating the molecular and cellular mechanisms of DDX41's functions in hematopoietic cells, focusing on its role in myelodysplastic syndromes (MDS) and related hematologic malignancies. The study aims to understand how DDX41 deficiency leads to G-quadruplex accumulation, defects in ribosome biogenesis, and p53-mediated apoptosis specifically in erythroid cells, with the goal of developing targeted therapies for DDX41 mutated MDS.