Award
National Institute of Allergy and Infectious Diseases 5R01AI189984-02
Crosstalk of Immune Dysregulation and Impaired Wound Healing in inherited STAT4-mediated Autoinflammatory Disease
Recipient
University of California, San Diego, La Jolla, CA
Award Amount
$398,959.00
Ceiling
$398,959.00
Awarded
December 16, 2025
Identifier
5R01AI189984-02
The NIH-funded project studies the genetic role of STAT4 in a severe pediatric autoinflammatory disease affecting wound healing and immune regulation, aiming to develop targeted therapies.
Description
This project aims to investigate the role of STAT4 as the genetic etiology underlying an autoinflammatory disease causing impaired wound healing, vascular damage, and altered immunoregulation known as disabling pansclerotic morphea. The studies focus on targeting mechanisms of inflammation, angiogenesis, and immune-stromal crosstalk to understand disease progression and develop therapeutic strategies.