Award
National Institute of Allergy and Infectious Diseases 5R21AI182745-02
Investigating ploidy modulation as a strategy to improve antibiotic activity
Recipient
Princeton University
Award Amount
$246,000.00
Ceiling
$246,000.00
Awarded
January 22, 2025
Identifier
5R21AI182745-02
NIH grant awarded to Princeton University to study bacterial ploidy modulation to improve antibiotic effectiveness and reduce infection relapse.
Description
This project aims to investigate how bacterial chromosome copy number (ploidy) impacts persistence to fluoroquinolone antibiotics and other antibiotics, with the goal of identifying compounds that can modulate ploidy to enhance antibiotic efficacy and reduce relapse infections.