Award
National Cancer Institute 5R01CA187975-10
Regulation of stem-like CD8+ T cells and their role in immunotherapy
Recipient
Brigham and Women's Hospital, Boston, MA, United States
Award Amount
$403,393.00
Ceiling
$403,393.00
Awarded
April 10, 2025
Identifier
5R01CA187975-10
Research project funded by the National Cancer Institute to study the regulation and role of stem-like CD8+ T cells in cancer immunotherapy, focusing on improving immune checkpoint blockade responses.
Description
This project aims to understand the regulation of stem-like CD8+ tumor-infiltrating lymphocytes (TILs), their interaction with antigen-presenting cells in the tumor microenvironment, and how modulation of these cells influences immune checkpoint blockade efficacy in cancer therapy.