Award
NIH Reporter #5R01HL168081-03
Impact of circulating and tissue-specific lipids on vascular function and insulin sensitivity in chronic night shift workers
Recipient
Colorado State University, Fort Collins, CO, United States
Award Amount
$664,185.00
Ceiling
$664,185.00
Awarded
May 15, 2026
Identifier
5R01HL168081-03
This NIH-funded project investigates how timed eating interventions can mitigate cardiometabolic disease risk in night shift workers by improving vascular function and insulin sensitivity through lipid regulation.
Description
The project aims to improve cardiometabolic health in free-living shift workers by using a circadian-based eating model (time-restricted eating) to reduce lipids and improve blood pressure, vascular function, insulin sensitivity, and glucose homeostasis. The study will conduct a randomized crossover trial in 50 non-rotating night shift workers with overweight or obesity to test the hypothesis that eliminating food intake during the biological night improves health markers associated with cardiovascular disease and Type 2 diabetes risk.