Award
National Eye Institute 2R01EY024602-11
Ocular Immune Regulation by Mesenchymal Stem Cells
Recipient
Schepens Eye Research Institute, Boston, MA, United States
Award Amount
$1,477,500.00
Ceiling
$1,477,500.00
Awarded
September 04, 2025
Identifier
2R01EY024602-11
The award supports research to understand how mesenchymal stem cells regulate immune responses in the eye, particularly in the context of corneal transplantation, to improve graft survival and develop new therapies for ocular inflammation.
Description
This is a competitive renewal application to further define the immunoregulatory function of mesenchymal stem cells (MSCs) in ocular inflammation. The project aims to elucidate the molecular mechanisms by which MSCs directly interact with T cells to regulate alloimmunity, with potential therapeutic applications in transplantation and T cell-mediated inflammatory disorders.