Award
National Institute of Allergy and Infectious Diseases 1R21AI182508-01A1
Mingling life imaging and cell subpopulations expression analysis in NHP lungs targeted with exosome associated double AAV vectors
Recipient
University of Minnesota, Minneapolis, MN
Award Amount
$437,250.00
Ceiling
$437,250.00
Awarded
June 25, 2025
Identifier
1R21AI182508-01A1
The project aims to develop safe and effective adeno-associated virus vectors for lung-directed gene therapy, testing them in non-human primate models to overcome delivery barriers and improve gene transfer efficacy in airway epithelial cells, particularly basal cells.
Description
This NIH grant opportunity supports research on advanced gene delivery vectors targeting lung tissues, with a focus on safety, efficacy, and long-term expression in relevant cell populations, using NHP models for translational relevance.