Award
National Institute of General Medical Sciences 1R01GM164296-01
Understanding Mammalian Golgi Trafficking Mechanisms
Recipient
Yale University, New Haven, CT, United States
Award Amount
$605,140.00
Ceiling
$605,140.00
Awarded
May 14, 2026
Identifier
1R01GM164296-01
The award funds research to understand lipid-mediated trafficking mechanisms in the mammalian Golgi apparatus, focusing on protein sorting and palmitoylation's role, with implications for cancer and neurodegenerative diseases.
Description
This project aims to elucidate the cellular and molecular mechanisms of a novel lipid-mediated pathway through the mammalian Golgi complex. The Golgi apparatus is responsible for sorting, post-translational modification, and trafficking of proteins and lipids to distinct cellular locations. Alterations in Golgi structure and function are linked to cancer and neuropathology. The study will investigate how palmitoylation in the early secretory pathway influences protein sorting and trafficking, focusing on machinery such as TUG/ASPCR1 and associated tether and SNARE fusion components. The research will examine the pathway's role in trafficking important cargo like glucose transporters and G protein-coupled receptors, providing insights into cell biology and implications for cancer and neurodegenerative diseases.