Award
National Institute of Environmental Health Sciences 5R01ES034251-04
Role of epigenetic crosstalks in directing locus sensitivity to arsenic
Recipient
University of California Los Angeles
Award Amount
$464,523.00
Ceiling
$464,523.00
Awarded
December 19, 2025
Identifier
5R01ES034251-04
Research project funded by NIEHS to study epigenetic mechanisms affecting sensitivity to arsenic exposure in mouse embryonic stem cells.
Description
This project aims to understand how epigenetic crosstalks influence locus-specific sensitivity to arsenic exposure, using mouse embryonic stem cells as a model. The research will characterize genome-wide changes in DNA methylation and histone modifications, investigate the role of the arsenic methyltransferase AS3MT, and examine the reprogrammability of arsenic-induced epigenetic alterations during germ cell differentiation.