Award
National Heart, Lung, and Blood Institute 5R01HL071158-22
Acid, Succinate and Glyoxal Metabolism in Ischemia
Recipient
University of Rochester, School of Medicine & Dentistry
Award Amount
$425,788.00
Ceiling
$425,788.00
Awarded
April 15, 2025
Identifier
5R01HL071158-22
Research project funded by NHLBI to study metabolic processes in heart attack and develop potential therapeutics targeting cardiac metabolism and ischemia-reperfusion injury.
Description
This project investigates key metabolic events during and after heart attack, focusing on how manipulating these events can impact outcomes, particularly in conditions of chronic hyperglycemia such as diabetes. It aims to study cardioprotective metabolic signaling events downstream of glycolysis, including the roles of pH, succinate, and methylglyoxal (MGO), and to develop ALKBH7 inhibitors as drugs using experimental systems like adult cardiomyocytes, perfused hearts, metabolomics, and engineered mice.