Award
National Institute of Allergy and Infectious Diseases 5R01AI137168-09
Characterizing the Mechanism of DPP8/9 Inhibitor-Induced Pyroptosis
Recipient
Sloan-Kettering Inst Can Research
Award Amount
$523,794.00
Ceiling
$523,794.00
Awarded
June 09, 2026
Identifier
5R01AI137168-09
This award funds research to characterize how DPP8/9 inhibitors induce pyroptosis by studying inflammasome activation mechanisms, supported by NIH grant PA-20-185.
Description
The project aims to study the molecular mechanisms of inflammasome activation related to cell homeostasis and innate immunity. The work involves understanding the role of reductive stress and Xaa-Pro peptide accumulation in inflammasome activation. The project is funded by NIH grant PA-20-185.