Award
National Institute of Diabetes and Digestive and Kidney Diseases 1R01DK142678-01A1
The molecular and physiologic effects of calcineurin inhibitors on WNK body bimolecular condensates
Recipient
University of Pittsburgh at Pittsburgh, Pittsburgh, PA, United States
Award Amount
$769,882.00
Ceiling
$769,882.00
Awarded
April 17, 2026
Identifier
1R01DK142678-01A1
This NIH-funded project studies the effects of calcineurin inhibitors on WNK body biomolecular condensates to understand and mitigate side effects in organ transplant patients, aiming to improve therapeutic strategies.
Description
The project investigates how calcineurin inhibitors, such as tacrolimus, influence WNK body biomolecular condensates and their role in side effects like hypertension, hyperkalemia, and metabolic acidosis in organ transplant patients. It aims to define cellular mechanisms, test mouse models, and analyze human kidney biopsies to validate WNK bodies as pharmacological targets and improve patient management.